You're not going to be able to drain the block without moving the front turbo to get to the drain plug, the rear is a little more accessible but still not a task I would want to do... trust me it's a PITA. I would be worried about rust/corrosion TBH.
Not just the seal, the bearings themselves are at risk. I'm not 100% sure about ours but many (most?) water pumps have the bearings exposed to the coolant, and use the coolant to lubricate and cool the bearing. Draining the coolant for long periods runs the risk of pitting and corrosion ruining the bearing which will make sort work of the pump.
Where's it leaking? Any chance you could temporarily seal it up?
Pull off the right side manifold. After that you can remove the tube and replace your o-ring.
While someone else may know better All the water pumps I have removed over the years only had their bearings expose to coolant after failure. I recognise in the quest to make things super crappy cheap that may have changed.
The best part about an antifreeze product is that there are additives to protect from corrosion. Mostly corrosion clogs up heater cores and then radiators, but it also interferes with cooling efficiency. Use a flush product to clean things out after repairing your leak(s) and then fill with antifreeze.
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